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apalutamide will minimize the extent or result of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with medication that happen to be CYP2C19 substrates may result in decrease publicity to those prescription drugs.enasidenib will enhance the level